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Not redeemable for cash. Limited to stock on hand. Sign Up Today Do you love tech deals? Therefore, caution should be exercised when considering the use of a quinolone in patients who are already receiving an NSAID.
When using phenytoin concomitantly with diclofenac, monitoring of phenytoin plasma concentrations is recommended due to an expected increase in exposure to phenytoin.
These agents can induce a delay or decrease in absorption of diclofenac. Clinical studies have shown that Diclofenac Potassium tablets can be given together with oral antidiabetic agents without influencing their clinical effect.
However there have been isolated reports of hypoglycaemic and hyperglycaemic effects which have required adjustment to the dosage of hypoglycaemic agents.
For this reason, monitoring of the blood glucose level is recommended as a precautionary measure during concomitant therapy. Drugs known to cause hyperkalemia: Concomitant treatment with potassium-sparing diuretics, ciclosporin, tacrolimus or trimethoprim may be associated with increased serum potassium levels, which should therefore be monitored frequently see section 4.
Caution is recommended when co-prescribing diclofenac with potent CYP2C9 inhibitors such as voriconazole , which could result in a significant increase in peak plasma concentrations and exposure to diclofenac due to inhibition of diclofenac metabolism.
Data from epidemiological studies suggest an increased risk of miscarriage and or cardiac malformation and gastroschisis after use of a prostaglandin synthesis inhibitor in early pregnancy.
The risk is believed to increase with dose and duration of therapy. In animals, administration of a prostaglandin synthesis inhibitor has shown to result in increased pre-and post-implantation loss and embryo-foetal lethality.
In addition, increased incidences of various malformations, including cardiovascular, have been reported in animals given a prostaglandin synthesis inhibitor during organogenetic period.
NSAIDs should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.
If diclofenac is used by a woman attempting to conceive, or during the 1 st or 2 nd trimesters of pregnancy, the dose should be kept as low and duration of treatment as short as possible.
During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to:. Therefore Diclofenac should not be administered during breast feeding in order to avoid undesirable effects in the infant see section 5.
As with other NSAIDs, the use of diclofenac may impair female fertility and is not recommended in women attempting to conceive.
In women who may have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of diclofenac should be considered.
Undesirable effects such as dizziness, drowsiness, fatigue and visual disturbances are possible after taking NSAIDs. If affected, patients should not drive or operate machinery.
Adverse reactions are ranked under the heading of frequency, the most frequent first, using the following convention:. The following undesirable effects include those reported with other short-term or long-term use.
Blood and lymphatic system disorders. Thrombocytopenia, leucopoenia, anaemia including haemolytic and aplastic anaemia , agranulocytosis.
Gastritis, gastrointestinal haemorrhage, haematemesis, diarrhoea haemorrhagic, melaena, gastrointestinal ulcer with or without bleeding or perforation sometimes fatal particularly in the elderly.
Acute renal failure, haematuria, proteinuria, nephrotic syndrome, interstitial nephritis, renal papillary necrosis. Clinical trial and epidemiological data consistently point towards an increased risk of arterial thrombotic events for example myocardial infarction or stroke associated with the use of diclofenac, particularly at high dose mg daily and in long term treatment.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme website: There is no typical clinical picture resulting from diclofenac over dosage.
Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhoea, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, fainting, occasionally convulsions.
In rare cases of significant poisoning acute renal failure and liver damage are possible. Within one hour of ingestion of a potentially toxic amount, activated charcoal should be considered.
Alternatively, in adults, gastric lavage should be considered within one hour of ingestion of a potentially life-threatening overdose.
Good urine output should be ensured. Special measures such as forced diuresis, dialysis or haemo-perfusion are probably of no help in eliminating NSAIDs, including diclofenac, due to high protein binding and extensive metabolism.
Patients should be observed for at least four hours after ingestion of potentially toxic amounts. Frequent or prolonged convulsions should be treated with intravenous diazepam.
Supportive measures should be given for complications such as hypotension, renal failure, gastrointestinal disorder, and respiratory depression.
Diclofenac Potassium tablets contain the potassium salt of diclofenac, a non-steroidal compound with pronounced and clinically demonstrable analgesic, anti-inflammatory and anti-pyretic properties.
Diclofenac is a potent inhibitor of prostaglandin biosynthesis and a modulator of arachidonic acid release and uptake. Diclofenac Potassium tablets have a rapid onset of action and are therefore suitable for the treatment of acute episodes of pain and inflammation.
In migraine attacks Diclofenac Potassium tablets have been shown to be effective in relieving the headache and in improving the accompanying symptom of nausea.
Diclofenac in vitro does not suppress proteoglycan biosynthesis in cartilage at concentrations equivalent to the concentrations reached in human beings.
Diclofenac is rapidly and completely absorbed from sugar-coated tablets. Food intake does not affect absorption. Peak plasma concentration after one 50 mg sugar-coated tablet was 3.
The plasma concentrations show a linear relationship to the size of the dose. The estimated amount ingested by an infant consuming breast milk is equivalent to a 0.
Repeated oral administration of Diclofenac Potassium tablets for 8 days in daily doses of 50 mg t. The remainder of the dose is eliminated as metabolites through the bile in the faeces.
The biotransformation of diclofenac involves partly glucuronidation of the intact molecule but mainly single and multiple hydroxylation followed by glucuronidation.
The age of the patient has no influence on the absorption, metabolism, or excretion of diclofenac. In patients suffering from renal impairment, no accumulation of the unchanged active substance can be inferred from the single-dose kinetics when applying the usual dosage schedule.
However, the metabolites are ultimately cleared through the bile. In the presence of impaired hepatic function chronic hepatitis, non-decompensated cirrhosis the kinetics and metabolism are the same as for patients without liver disease.
Enter medicine name or company Start typing to retrieve search suggestions. Continue typing to refine. Diclofenac Potassium 50 mg Tablets.
Back to top Accord-UK Ltd contact details. Active ingredient diclofenac potassium. Last updated on eMC: Show table of contents Hide table of contents 1.
Name of the medicinal product 2. Qualitative and quantitative composition 3. Marketing authorisation holder 8. Marketing authorisation number s 9.
Date of revision of the text. This information is intended for use by health professionals. Each film-coated tablet contains 50 mg of diclofenac potassium Also contains Lecithin Soya E This medicine contains 0.
For a full list of excipients, see section 6. Film-coated tablets Reddish brown, circular, coated, biconvex tablets, diameter 9 mm. Rheumatoid arthritis Osteoarthrosis Low back pain Migraine attacks Acute musculo-skeletal disorders and trauma such as periarthritis especially frozen shoulder , tendinitis, tenosynovitis, bursitis, sprains, strains and dislocations; relief of pain in fractures Ankylosing spondylitis Acute gout Control of pain and inflammation in orthopaedic, dental and other minor surgery Pyrophosphate arthropathy and associated disorders.
To be taken preferably with or after food. The tablets should be swallowed whole with liquid Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms see section 4.
Adults The recommended daily dose is — mg in two or three divided doses. Paediatric population For children over 14 years of age, the recommended daily dose is mg in two or three divided doses.
Elderly The elderly are at increased risk of the serious consequences of adverse reactions. Renal impairment No adjustment of the starting dose is required for renally impaired patients see section 4.
Hepatic impairment No adjustment of the starting dose is required for hepatically impaired patients see section 4. Elderly Caution is indicated in the elderly on basic medical grounds.
SLE and mixed connective tissue disease: Cardiovascular, Renal and Hepatic Impairment: Hepatic Close medical surveillance is required when prescribing diclofenac to patients with impairment of hepatic function as their condition may be exacerbated.
Hepatitis may occur without prodromal symptoms. Use of Diclofenac Potassium tablets in patients with hepatic porphyria may trigger an attack.
Haematological Diclofenac Potassium tablets may reversibly inhibit platelet aggregation see section 4. Long term treatment All patients who are receiving long term treatment with non-steroidal, anti-inflammatory agents should be monitored as a precautionary measure eg renal function, hepatic function elevation of liver enzymes may occur and blood counts.
Respiratory disorders In patients with asthma, seasonal allergic rhinitis, swelling of the nasal mucosa i. Dermatological Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs see section 4.
Impaired female fertility The use of Diclofenac Potassium tablets may impair female fertility and is not recommended in women attempting to conceive.
During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to: Female fertility As with other NSAIDs, the use of diclofenac may impair female fertility and is not recommended in women attempting to conceive.
Adverse reactions are ranked under the heading of frequency, the most frequent first, using the following convention: Blood and lymphatic system disorders Very rare Thrombocytopenia, leucopoenia, anaemia including haemolytic and aplastic anaemia , agranulocytosis.
Unknown Neutropenia Immune system disorders Rare Hypersensitivity, anaphylactic and anaphylactoid reactions including hypotension and shock. Very rare Angioneurotic oedema including face oedema.
Psychiatric disorders Very rare Disorientation, depression, insomnia, nightmare, irritability, psychotic disorder.
Nervous system disorders Common Headache, dizziness. Unknown Confusion, hallucinations, disturbances of sensation malaise Eye disorders Very rare Visual disturbance, vision blurred, diplopia.
Ear and labyrinth disorders Common Vertigo. Very rare Tinnitus, hearing impaired. Cardiac disorders Very rare Palpitations, chest pain, cardiac failure, myocardial infarction.
Vascular disorders Very rare Hypertension, hypotension, vasculitis.We respect your privacy and take it very seriously. Wolfsburg hannover 96 tablet that listens Use your em rosenheim to get things done. Consider price, app availability, and operating system before you buy. HP Elite x2 G Kristi MonsonPharmD. Vascular disorders Very rare Hypertension, hypotension, vasculitis. Visual disturbance, vision blurred, diplopia. Windows 7 Professional 3. The risk is believed to increase with dose and duration of therapy. This interaction is mediated through accumulation of methotrexate resulting from impairment of renal excretion in the presence of the NSAID. Very rare Fulminant hepatitis, hepatic necrosis, hepatic failure. Selective serotonin reuptake inhibitors Best casino bonuses no deposit The tablets should be swallowed whole with liquid Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms see city zahnärzte stuttgart 4.
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